The latest:

WATCH | A ventilator, hallucinations and goodbyes:

A Ventilator, hallucinations, and good-byesCOVID-19 ravaged Paul Hemsing’s body and left him with deep physical and emotional scars. He hopes sharing his story saves someone else from having to go through the same thing. 5:27

AstraZeneca has requested emergency use authorization from U.S. regulators for its new treatment to prevent COVID-19 for people who respond poorly to vaccines because of a weakened immune system.

In a statement on Tuesday, the Anglo-Swedish drugmaker said it included data in its filing with the Food and Drug  Administration from a late-stage trial that showed the drug reduced the risk of people developing any COVID-19 symptoms by 77 per cent.

The antibody therapy called AZD7442 could protect people who do not have a strong enough immune response to COVID-19 vaccines or to supplement a vaccination course for those, such as military personnel, who need to boost their protection further, AstraZeneca has said.

While vaccines rely on an intact immune system to develop targeted antibodies and infection-fighting cells, AZD7442  contains lab-made antibodies designed to linger in the body for months to contain the virus in case of an infection.

A U.S. authorization for AZD7442 — based on two antibodies discovered by Vanderbilt University Medical Center in the United States — could be a major win for AstraZeneca, whose widely used COVID-19 vaccine has yet to be approved by U.S. authorities.

Talks regarding supply agreements for AZD7442 are ongoing with the United States and other governments, AstraZeneca said.

COVID-19 therapies based on the same class of monoclonal antibodies are being developed by rivals Regeneron, Eli  Lilly and GlaxoSmithKline with partner Vir, competing for a role in COVID-19 treatment and prevention. But Astra’s filing has cemented its lead in prevention.

Trial results on the AZD7442 therapy, first published in August, were taken three months after injection, but the company  hopes it can tout the shot as a year-long shield as trial investigators will follow up with participants as far out as 15  months. 

What’s happening across Canada

WATCH | Stories from Alberta’s ICUs during COVID’s 4th wave:

Stories from Alberta’s ICUs during the COVID-19 fourth waveAlberta’s ICUs have 257 COVID-19 patients. That’s more than any other province. But the number alone doesn’t explain the impact. In a place where small details and moments matter, struggling ICUs mean struggling patients. This is the situation they see. 11:32 What’s happening around the world

As of early Tuesday, more than 235.4 million cases of COVID-19 had been reported worldwide, according to Johns Hopkins University’s coronavirus-tracking tool. The reported global death toll stood at more than 4.8 million.

In Asia, China reported no new local COVID-19 cases for the first time in more than three weeks.

In Europe, the Kremlin has implored people to get vaccinated, as Russian authorities mulled reintroducing health restrictions to cope with daily cases rising to their highest levels since January.

In the Americas, New York State’s largest health-care provider has fired 1,400 employees who refused to get vaccinations.

Source From CBC News

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